59 research outputs found
Concentrations of strontium, barium, cadmium, copper, zinc, manganese, chromium, antimony, selenium, and lead in the liver and kidneys of dogs according to age, gender, and the occurrence of chronic kidney disease
This study was conducted to measure the concentrations of strontium (Sr),
barium (Ba), cadmium (Cd), copper (Cu), zinc (Zn), manganese (Mn), chromium
(Cr), antimony (Sb), selenium (Se), and lead (Pb) in canine liver, renal
cortex, and renal medulla, and the association of these concentrations with
age, gender, and occurrence of chronic kidney disease (CKD). Tissues from 50
dogs were analyzed using inductively coupled plasma mass spectrometry. Cu, Zn,
and Mn levels were highest in the liver followed by the renal cortex and renal
medulla. The highest Sr, Cd, and Se concentrations were measured in the renal
cortex while lower levels were found in the renal medulla and liver. Female
dogs had higher tissue concentrations of Sr (liver and renal medulla), Cd
(liver), Zn (liver and renal cortex), Cr (liver, renal cortex, and renal
medulla), and Pb (liver) than male animals. Except for Mn and Sb, age-
dependent variations were observed for all element concentrations in the
canine tissues. Hepatic Cd and Cr concentrations were higher in dogs with CKD.
In conclusion, the present results provide new knowledge about the storage of
specific elements in canine liver and kidneys, and can be considered important
reference data for diagnostic methods and further investigations
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